Cell Line Development

[fusion_builder_container hundred_percent=”no” hundred_percent_height=”no” hundred_percent_height_scroll=”no” align_content=”stretch” flex_align_items=”flex-start” flex_justify_content=”flex-start” hundred_percent_height_center_content=”yes” equal_height_columns=”no” container_tag=”div” hide_on_mobile=”no” status=”published” class=”bannersec” id=”bnr” padding_top=”130″ padding_bottom=”120″ border_sizes_top=”0px” border_sizes_right=”0px” border_sizes_bottom=”0px” border_sizes_left=”0px” border_style=”solid” box_shadow=”no” box_shadow_blur=”0″ box_shadow_spread=”0″ gradient_end_color=”rgba(0,70,123,0)” gradient_start_position=”0″ gradient_end_position=”93″ gradient_type=”linear” radial_direction=”center center” linear_angle=”180″ background_color=”#00467b” background_image=”http://herabiolabs.com/wp-content/uploads/2022/08/cell-line-development.png” background_position=”right bottom” background_repeat=”no-repeat” fade=”no” background_parallax=”none” enable_mobile=”no” parallax_speed=”0.3″ background_blend_mode=”none” video_aspect_ratio=”16:9″ video_loop=”yes” video_mute=”yes” absolute=”off” absolute_devices=”small,medium,large” sticky=”off” sticky_devices=”small-visibility,medium-visibility,large-visibility” sticky_transition_offset=”0″ scroll_offset=”0″ animation_direction=”left” animation_speed=”0.3″ filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″ type=”flex”][fusion_builder_row][fusion_builder_column type=”1_1″ type=”1_1″ layout=”1_1″ align_self=”auto” content_layout=”column” align_content=”flex-start” valign_content=”flex-start” content_wrap=”wrap” center_content=”no” target=”_self” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” order_medium=”0″ order_small=”0″ hover_type=”none” border_style=”solid” box_shadow=”no” box_shadow_blur=”0″ box_shadow_spread=”0″ background_type=”single” gradient_start_position=”0″ gradient_end_position=”100″ gradient_type=”linear” radial_direction=”center center” linear_angle=”180″ background_position=”left top” background_repeat=”no-repeat” background_blend_mode=”none” filter_type=”regular” filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″ animation_direction=”left” animation_speed=”0.3″ first=”true” last=”true” border_position=”all” min_height=”” link=””][fusion_title title_type=”text” loop_animation=”once” rotation_effect=”bounceIn” display_time=”1200″ highlight_effect=”strikethrough” highlight_width=”9″ highlight_top_margin=”0″ title_link=”off” link_target=”_self” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” class=”hed1″ content_align=”center” size=”2″ text_color=”#ffffff” text_shadow=”yes” text_shadow_vertical=”3″ text_shadow_horizontal=”3″ text_shadow_blur=”3″ text_shadow_color=”#595959″ margin_top=”35″ gradient_font=”no” gradient_start_position=”0″ gradient_end_position=”100″ gradient_type=”linear” radial_direction=”center center” linear_angle=”180″ style_type=”none” animation_direction=”left” animation_speed=”0.3″]

Cell Line Development Services

[/fusion_title][fusion_text rule_style=”default” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” margin_bottom=”35px” fusion_font_family_text_font=”Roboto” fusion_font_variant_text_font=”300″ font_size=”24″ line_height=”30px” text_transform=”none” text_color=”#ffffff” animation_direction=”left” animation_speed=”0.3″]

Stable protein expression in CleanCut GS CHO cells for bioproduction

[/fusion_text][fusion_button link=”http://herabiolabs.com/contact-us/” title=”Contact Us” target=”_self” alignment=”center” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” color=”custom” button_gradient_top_color_hover=”#19a64a” button_gradient_top_color=”#19a64a” button_gradient_bottom_color_hover=”#19a64a” button_gradient_bottom_color=”#19a64a” accent_hover_color=”#ffffff” accent_color=”#ffffff” type=”flat” border_hover_color=”#ffffff” border_color=”#ffffff” size=”xlarge” stretch=”no” margin_bottom=”35″ icon_position=”left” icon_divider=”no” hover_transition=”none” animation_direction=”left” animation_speed=”1″ animation_delay=”0″]Contact Us[/fusion_button][/fusion_builder_column][/fusion_builder_row][/fusion_builder_container][fusion_builder_container background_color=”#ececf1″ background_parallax=”none” enable_mobile=”no” parallax_speed=”0.3″ background_repeat=”no-repeat” background_position=”left top” video_aspect_ratio=”16:9″ video_mute=”yes” video_loop=”yes” fade=”no” border_style=”solid” padding_top=”50″ padding_bottom=”35″ hundred_percent=”no” equal_height_columns=”no” hide_on_mobile=”no” class=”sec11″ border_sizes_top=”0px” border_sizes_bottom=”0px” border_sizes_left=”0px” border_sizes_right=”0px” flex_column_spacing=”0px” type=”flex”][fusion_builder_row][fusion_builder_column type=”1_1″ type=”1_1″ layout=”1_1″ align_self=”auto” content_layout=”column” align_content=”flex-start” valign_content=”flex-start” content_wrap=”wrap” spacing=”yes” center_content=”yes” target=”_self” min_height=”none” hide_on_mobile=”no” sticky_display=”normal,sticky” order_medium=”0″ order_small=”0″ margin_bottom=”0″ hover_type=”none” border_sizes_top=”0px” border_sizes_right=”0px” border_sizes_bottom=”0px” border_sizes_left=”0px” border_style=”solid” box_shadow=”no” box_shadow_blur=”0″ box_shadow_spread=”0″ background_type=”single” gradient_start_position=”0″ gradient_end_position=”100″ gradient_type=”linear” radial_direction=”center center” linear_angle=”180″ background_position=”left top” background_repeat=”no-repeat” background_blend_mode=”none” filter_type=”regular” filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″ animation_direction=”down” animation_speed=”0.1″ last=”true” border_position=”all” first=”true” link=””][fusion_text rule_style=”default” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” margin_right=” ” margin_left=” ” fusion_font_family_text_font=”Roboto” fusion_font_variant_text_font=”300″ line_height=”30px” text_transform=”none” animation_direction=”left” animation_speed=”0.3″]

At Hera, we focus on engineering suspension CHO cells optimized for scale-up in GMP bioproduction. Our proprietary gene editing platform—featuring Cas-CLOVER for targeted knockouts and integrations, CleanCut GS knockout CHO host cells, and Harbor-IN transposase for stable integration—enables the generation of high-performance cell lines for therapeutic protein production and other advanced applications.

What sets Hera apart is our full commercial licensing and freedom to operate (FTO) for every component of this advanced gene editing platform, enabling us to deliver top-producing cell clones to clients as a fee-for-service without any downstream royalties or payment obligations.

Harnessing Harbor-IN Transposase for Cell Line Development

[/fusion_title][/fusion_builder_column][fusion_builder_column type=”1_2″ type=”1_2″ layout=”3_5″ align_self=”auto” content_layout=”column” align_content=”flex-start” valign_content=”flex-start” content_wrap=”wrap” spacing=”yes” center_content=”no” target=”_self” hide_on_mobile=”no” sticky_display=”normal,sticky” class=”max463-right spl-anchor mr55″ order_medium=”0″ order_small=”0″ spacing_left=”2%” margin_bottom=”20px” hover_type=”none” border_sizes_top=”0px” border_sizes_right=”0px” border_sizes_bottom=”0px” border_sizes_left=”0px” border_style=”solid” box_shadow=”no” box_shadow_blur=”0″ box_shadow_spread=”0″ background_type=”single” gradient_start_position=”0″ gradient_end_position=”100″ gradient_type=”linear” radial_direction=”center center” linear_angle=”180″ background_position=”left top” background_repeat=”no-repeat” background_blend_mode=”overlay” filter_type=”regular” filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″ animation_direction=”down” animation_speed=”0.1″ last=”false” border_position=”all” first=”true” min_height=”” link=””][fusion_imageframe image_id=”9607|full” custom_aspect_ratio=”100″ lightbox=”no” linktarget=”_self” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” align_medium=”none” align_small=”none” align=”center” hover_type=”none” caption_style=”off” caption_align_medium=”none” caption_align_small=”none” caption_align=”none” caption_title_tag=”2″ animation_direction=”left” animation_speed=”0.3″ filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″ max_width=”380″]http://herabiolabs.com/wp-content/uploads/2025/07/Harbor-IN-with-surface-modelling.png[/fusion_imageframe][/fusion_builder_column][fusion_builder_column type=”1_2″ type=”1_2″ layout=”2_3″ align_self=”center” content_layout=”column” align_content=”flex-start” valign_content=”flex-start” content_wrap=”wrap” spacing=”yes” center_content=”no” target=”_self” hide_on_mobile=”no” sticky_display=”normal,sticky” class=”max463-right spl-anchor ml55″ order_medium=”0″ order_small=”0″ spacing_left=”2%” margin_bottom=”0px” hover_type=”none” border_sizes_top=”0px” border_sizes_right=”0px” border_sizes_bottom=”0px” border_sizes_left=”0px” border_style=”solid” box_shadow=”no” box_shadow_blur=”0″ box_shadow_spread=”0″ background_type=”single” gradient_start_position=”0″ gradient_end_position=”100″ gradient_type=”linear” radial_direction=”center center” linear_angle=”180″ background_position=”left top” background_repeat=”no-repeat” background_blend_mode=”overlay” filter_type=”regular” filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″ animation_direction=”down” animation_speed=”0.1″ last=”true” border_position=”all” first=”false” min_height=”” link=””][fusion_text rule_style=”default” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” fusion_font_family_text_font=”Roboto” fusion_font_variant_text_font=”300″ line_height=”30px” text_transform=”none” animation_direction=”left” animation_speed=”0.3″]

1. High Efficiency: improves productivity and reduces time & cost

2. Large Integration Capacity: supports large/multi-gene payloads

3. Stability: long-term expression over extended culture

Achieve high titers and long-term stability using Harbor-IN. Trusted by pharmaceutical companies and CDMO’s around the world, Harbor-IN enables high titers and industry leading cell specific productivity.

Harbor-IN + CleanCut GS for Service-Based Cell Line Development

[/fusion_title][fusion_text rule_style=”default” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” text_transform=”none” animation_direction=”left” animation_speed=”0.3″]

Hera integrates the Harbor-IN transposase system with CleanCut GS CHO cells to provide a turnkey platform for commercial cell line development services. Harbor-IN enables stable integration of large expression cassettes at transcriptionally active, open chromatin regions, while CleanCut GS cells allow for stringent selection and high productivity.

This combination provides an ideal solution for generating high-yield, stable production clones, along with compatibility with GMP manufacturing requirements. With Hera’s integrated platform and expertise, clients can rapidly advance from transgene design to cell banks with no downstream licensing fees.

[/fusion_text][fusion_imageframe custom_aspect_ratio=”100″ lightbox=”no” linktarget=”_self” align_medium=”none” align_small=”none” align=”center” hover_type=”none” magnify_duration=”120″ scroll_height=”100″ scroll_speed=”1″ caption_style=”off” caption_align_medium=”none” caption_align_small=”none” caption_align=”none” caption_title_tag=”2″ animation_direction=”left” animation_speed=”0.3″ animation_delay=”0″ hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″ image_id=”9608|full” margin_top=”20″ max_width=”600″]http://herabiolabs.com/wp-content/uploads/2025/07/5G2-titer-and-Qp.png[/fusion_imageframe][/fusion_builder_column][fusion_builder_column type=”1_1″ type=”1_1″ layout=”1_1″ align_self=”auto” content_layout=”column” align_content=”flex-start” valign_content=”flex-start” content_wrap=”wrap” center_content=”no” target=”_self” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” order_medium=”0″ order_small=”0″ hover_type=”none” border_style=”solid” box_shadow=”no” box_shadow_blur=”0″ box_shadow_spread=”0″ background_type=”single” gradient_start_position=”0″ gradient_end_position=”100″ gradient_type=”linear” radial_direction=”center center” linear_angle=”180″ background_position=”left top” background_repeat=”no-repeat” background_blend_mode=”none” filter_type=”regular” filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″ animation_direction=”left” animation_speed=”0.3″ last=”true” border_position=”all” first=”true” margin_top=”40″ margin_bottom=”0px” min_height=”” link=””][fusion_button target=”_self” alignment=”center” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” color=”custom” button_gradient_top_color=”#19a64a” button_gradient_bottom_color=”#19a64a” button_gradient_top_color_hover=”#19a64a” button_gradient_bottom_color_hover=”#19a64a” accent_color=”#ffffff” accent_hover_color=”#ffffff” type=”flat” border_color=”#ffffff” border_hover_color=”#ffffff” size=”xlarge” stretch=”no” icon_position=”left” icon_divider=”no” animation_direction=”left” animation_speed=”1″ link=”/contact-us/”]Contact Us[/fusion_button][/fusion_builder_column][/fusion_builder_row][/fusion_builder_container][fusion_builder_container type=”flex” hundred_percent=”no” hundred_percent_height=”no” hundred_percent_height_scroll=”no” align_content=”stretch” flex_align_items=”flex-start” flex_justify_content=”flex-start” hundred_percent_height_center_content=”yes” equal_height_columns=”no” container_tag=”div” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” status=”published” class=”hed1″ margin_top=”0px” margin_bottom=”0px” border_style=”solid” box_shadow=”no” box_shadow_blur=”0″ box_shadow_spread=”0″ gradient_start_position=”0″ gradient_end_position=”100″ gradient_type=”linear” radial_direction=”center center” linear_angle=”180″ background_color=”#dbdbdb” background_position=”center center” background_repeat=”no-repeat” fade=”no” background_parallax=”none” enable_mobile=”no” parallax_speed=”0.3″ background_blend_mode=”none” video_aspect_ratio=”16:9″ video_loop=”yes” video_mute=”yes” absolute=”off” absolute_devices=”small,medium,large” sticky=”off” sticky_devices=”small-visibility,medium-visibility,large-visibility” sticky_transition_offset=”0″ scroll_offset=”0″ animation_direction=”left” animation_speed=”0.3″ filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″ padding_bottom=”10px”][fusion_builder_row][fusion_builder_column type=”1_1″ type=”1_1″ layout=”1_2″ last=”true” spacing=”yes” center_content=”no” hide_on_mobile=”no” background_repeat=”no-repeat” background_position=”left top” border_position=”all” border_style=”solid” margin_bottom=”20px” animation_type=”0″ animation_direction=”down” animation_speed=”0.1″ border_sizes_top=”0px” border_sizes_bottom=”0px” border_sizes_left=”0px” border_sizes_right=”0px” first=”true” spacing_left=”2%” hover_type=”none” background_blend_mode=”overlay” min_height=”” link=””][fusion_text rule_style=”default” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” margin_top=”65px” margin_bottom=”30px” fusion_font_family_text_font=”Roboto” fusion_font_variant_text_font=”300″ line_height=”30px” text_transform=”none” animation_direction=”left” animation_speed=”0.3″]

Our Stable Cell Line Development Process

Hera’s streamlined cell line development process begins with the design and construction of optimized transposon vectors encoding the client’s genes of interest. We then perform transfection, GS selection, and single-cell cloning.

Selected clones are screened for expression and growth, with accurate titer measurements used to rank productivity. Up to 10 high-performing monoclonal clones are expanded, QC tested and banked in accordance with regulatory guidance.

[/fusion_text][/fusion_builder_column][/fusion_builder_row][/fusion_builder_container][fusion_builder_container type=”flex” hundred_percent=”no” hundred_percent_height=”no” hundred_percent_height_scroll=”no” align_content=”stretch” flex_align_items=”flex-start” flex_justify_content=”flex-start” hundred_percent_height_center_content=”yes” equal_height_columns=”no” container_tag=”div” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” status=”published” border_style=”solid” box_shadow=”no” box_shadow_blur=”0″ box_shadow_spread=”0″ gradient_start_position=”0″ gradient_end_position=”100″ gradient_type=”linear” radial_direction=”center center” linear_angle=”180″ background_color=”#ffffff” background_position=”center center” background_repeat=”no-repeat” fade=”no” background_parallax=”none” enable_mobile=”no” parallax_speed=”0.3″ background_blend_mode=”none” video_aspect_ratio=”16:9″ video_loop=”yes” video_mute=”yes” absolute=”off” absolute_devices=”small,medium,large” sticky=”off” sticky_devices=”small-visibility,medium-visibility,large-visibility” sticky_transition_offset=”0″ scroll_offset=”0″ animation_direction=”left” animation_speed=”0.3″ filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″ padding_top=”65px” padding_bottom=”40px”][fusion_builder_row][fusion_builder_column type=”1_1″ type=”1_1″ layout=”1_1″ align_self=”auto” content_layout=”column” align_content=”flex-start” valign_content=”flex-start” content_wrap=”wrap” center_content=”no” target=”_self” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” order_medium=”0″ order_small=”0″ hover_type=”none” border_style=”solid” box_shadow=”no” box_shadow_blur=”0″ box_shadow_spread=”0″ background_type=”single” gradient_start_position=”0″ gradient_end_position=”100″ gradient_type=”linear” radial_direction=”center center” linear_angle=”180″ background_color=”#ffffff” background_position=”left top” background_repeat=”no-repeat” background_blend_mode=”none” filter_type=”regular” filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″ animation_direction=”left” animation_speed=”0.3″ last=”true” border_position=”all” first=”true” min_height=”” link=””][fusion_imageframe image_id=”9622|full” custom_aspect_ratio=”100″ lightbox=”no” alt=”stable cell line creation process” link=” ” linktarget=”_self” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” align_medium=”none” align_small=”none” align=”none” hover_type=”none” margin_bottom=”25″ caption_style=”off” caption_align_medium=”none” caption_align_small=”none” caption_align=”none” caption_title_tag=”2″ animation_direction=”left” animation_speed=”0.3″ filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″]http://herabiolabs.com/wp-content/uploads/2025/07/stable-cell-line-dev_revised.png[/fusion_imageframe][/fusion_builder_column][/fusion_builder_row][/fusion_builder_container][fusion_builder_container type=”flex” hundred_percent=”no” hundred_percent_height=”no” hundred_percent_height_scroll=”no” align_content=”stretch” flex_align_items=”flex-start” flex_justify_content=”flex-start” flex_wrap=”wrap” hundred_percent_height_center_content=”yes” equal_height_columns=”no” container_tag=”div” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” status=”published” spacing_medium=”” spacing_small=”” padding_dimensions_medium=”” padding_dimensions_small=”” border_sizes=”” border_style=”solid” box_shadow=”no” box_shadow_blur=”0″ box_shadow_spread=”0″ gradient_start_color=”” gradient_end_color=”” gradient_start_position=”0″ gradient_end_position=”100″ gradient_type=”linear” radial_direction=”center center” linear_angle=”180″ background_position=”center center” background_repeat=”no-repeat” background_custom_size=”” background_custom_size_medium=”” background_custom_size_small=”” fade=”no” background_parallax=”none” enable_mobile=”no” parallax_speed=”0.3″ background_blend_mode=”none” background_slider_position=”” background_slider_skip_lazy_loading=”no” background_slider_loop=”yes” background_slider_pause_on_hover=”no” background_slider_slideshow_speed=”5000″ background_slider_animation=”fade” background_slider_direction=”up” background_slider_animation_speed=”800″ video_aspect_ratio=”16:9″ video_loop=”yes” video_mute=”yes” pattern_bg=”none” pattern_custom_bg=”” pattern_bg_color=”” pattern_bg_style=”default” pattern_bg_opacity=”100″ pattern_bg_size=”” pattern_bg_blend_mode=”normal” mask_bg=”none” mask_custom_bg=”” mask_bg_color=”” mask_bg_accent_color=”” mask_bg_style=”default” mask_bg_opacity=”100″ mask_bg_transform=”left” mask_bg_blend_mode=”normal” render_logics=”” logics=”” absolute=”off” absolute_devices=”small,medium,large” sticky=”off” sticky_devices=”small-visibility,medium-visibility,large-visibility” sticky_transition_offset=”0″ scroll_offset=”0″ animation_direction=”left” animation_color=”” animation_speed=”0.3″ animation_delay=”0″ filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″][fusion_builder_row][fusion_builder_column type=”1_1″ align_self=”auto” content_layout=”column” align_content=”flex-start” valign_content=”flex-start” content_wrap=”wrap” center_content=”no” column_tag=”div” target=”_self” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” type_medium=”” type_small=”” type=”1_1″ flex_grow_medium=”” flex_grow_small=”” flex_grow=”” flex_shrink_medium=”” flex_shrink_small=”” flex_shrink=”” order_medium=”0″ order_small=”0″ dimension_spacing_medium=”” dimension_spacing_small=”” dimension_spacing=”” dimension_margin_medium=”” dimension_margin_small=”” dimension_margin=”” padding_medium=”” padding_small=”” padding=”” hover_type=”none” border_sizes=”” border_style=”solid” border_radius=”” box_shadow=”no” dimension_box_shadow=”” box_shadow_blur=”0″ box_shadow_spread=”0″ background_type=”single” gradient_start_color=”” gradient_end_color=”” gradient_start_position=”0″ gradient_end_position=”100″ gradient_type=”linear” radial_direction=”center center” linear_angle=”180″ lazy_load=”avada” background_position=”left top” background_repeat=”no-repeat” background_custom_size=”” background_custom_size_medium=”” background_custom_size_small=”” background_blend_mode=”none” background_slider_position=”” background_slider_skip_lazy_loading=”no” background_slider_loop=”yes” background_slider_pause_on_hover=”no” background_slider_slideshow_speed=”5000″ background_slider_animation=”fade” background_slider_direction=”up” background_slider_animation_speed=”800″ render_logics=”” sticky=”off” sticky_devices=”small-visibility,medium-visibility,large-visibility” absolute=”off” absolute_props=”” filter_type=”regular” filter_hover_element=”self” filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″ transform_type=”regular” transform_hover_element=”self” transform_scale_x=”1″ transform_scale_y=”1″ transform_translate_x=”0″ transform_translate_y=”0″ transform_rotate=”0″ transform_skew_x=”0″ transform_skew_y=”0″ transform_scale_x_hover=”1″ transform_scale_y_hover=”1″ transform_translate_x_hover=”0″ transform_translate_y_hover=”0″ transform_rotate_hover=”0″ transform_skew_x_hover=”0″ transform_skew_y_hover=”0″ transform_origin=”” transition_duration=”300″ transition_easing=”ease” transition_custom_easing=”” motion_effects=”” scroll_motion_devices=”small-visibility,medium-visibility,large-visibility” animation_direction=”left” animation_color=”” animation_speed=”0.3″ animation_delay=”0″ min_height=”” last=”no” link=”” border_position=”all”][fusion_title title_type=”text” loop_animation=”once” rotation_effect=”bounceIn” display_time=”1200″ highlight_effect=”circle” highlight_width=”9″ highlight_top_margin=”0″ title_link=”off” link_target=”_self” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” class=”hedm” content_align=”center” size=”2″ text_shadow=”no” text_shadow_blur=”0″ gradient_font=”no” gradient_start_position=”0″ gradient_end_position=”100″ gradient_type=”linear” radial_direction=”center center” linear_angle=”180″ style_type=”none” animation_direction=”left” animation_speed=”0.3″ line_height=”var(–awb-typography2-line-height)” font_size=”48″ margin_bottom=”0″]Cas CLOVER for Host Cell Modifications and Targeted Integration[/fusion_title][/fusion_builder_column][/fusion_builder_row][/fusion_builder_container][fusion_builder_container hundred_percent=”no” hundred_percent_height=”no” hundred_percent_height_scroll=”no” align_content=”stretch” flex_align_items=”flex-start” flex_justify_content=”flex-start” hundred_percent_height_center_content=”yes” equal_height_columns=”yes” container_tag=”div” hide_on_mobile=”no” status=”published” margin_top=”0px” margin_bottom=”55px” padding_top=”0″ border_sizes_top=”0px” border_sizes_right=”0px” border_sizes_bottom=”0px” border_sizes_left=”0px” border_style=”solid” box_shadow=”no” box_shadow_blur=”0″ box_shadow_spread=”0″ gradient_start_position=”0″ gradient_end_position=”100″ gradient_type=”linear” radial_direction=”center center” linear_angle=”180″ background_color=”#ffffff” background_position=”left top” background_repeat=”no-repeat” fade=”no” background_parallax=”none” enable_mobile=”no” parallax_speed=”0.3″ background_blend_mode=”none” video_aspect_ratio=”16:9″ video_loop=”yes” video_mute=”yes” absolute=”off” absolute_devices=”small,medium,large” sticky=”off” sticky_devices=”small-visibility,medium-visibility,large-visibility” sticky_transition_offset=”0″ scroll_offset=”0″ animation_direction=”left” animation_speed=”0.3″ filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″ type=”flex” class=”sec3 zigzag-section nsec3″][fusion_builder_row][fusion_builder_column type=”1_3″ type=”1_3″ layout=”1_3″ align_self=”auto” content_layout=”column” align_content=”flex-start” valign_content=”flex-start” content_wrap=”wrap” spacing=”yes” center_content=”no” target=”_self” hide_on_mobile=”no” sticky_display=”normal,sticky” class=”mr55″ order_medium=”0″ order_small=”0″ margin_bottom=”20px” hover_type=”none” border_sizes_top=”0px” border_sizes_right=”0px” border_sizes_bottom=”0px” border_sizes_left=”0px” border_style=”solid” box_shadow=”no” box_shadow_blur=”0″ box_shadow_spread=”0″ background_type=”single” gradient_start_position=”0″ gradient_end_position=”100″ gradient_type=”linear” radial_direction=”center center” linear_angle=”180″ background_position=”left top” background_repeat=”no-repeat” background_blend_mode=”overlay” filter_type=”regular” filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″ animation_direction=”down” animation_speed=”0.1″ last=”true” border_position=”all” first=”false” spacing_right=”2%” min_height=”” link=””][fusion_imageframe image_id=”9623|full” custom_aspect_ratio=”100″ lightbox=”no” linktarget=”_self” hide_on_mobile=”no” sticky_display=”normal,sticky” class=”fullimg” align_medium=”none” align_small=”none” align=”center” style_type=”none” hover_type=”none” bordersize=”0px” borderradius=”0″ caption_style=”off” caption_align_medium=”none” caption_align_small=”none” caption_align=”none” caption_title_tag=”2″ animation_direction=”down” animation_speed=”0.1″ filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″]http://herabiolabs.com/wp-content/uploads/2025/07/Cas-CLOVER_600x600.jpg[/fusion_imageframe][fusion_imageframe image_id=”9624|full” custom_aspect_ratio=”100″ lightbox=”no” linktarget=”_self” hide_on_mobile=”no” sticky_display=”normal,sticky” class=”fullimg” align_medium=”none” align_small=”none” align=”center” style_type=”none” hover_type=”none” bordersize=”0px” borderradius=”0″ caption_style=”off” caption_align_medium=”none” caption_align_small=”none” caption_align=”none” caption_title_tag=”2″ animation_direction=”down” animation_speed=”0.1″ filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″]http://herabiolabs.com/wp-content/uploads/2025/07/CRISPR-Cas9_600x600.jpg[/fusion_imageframe][fusion_text columns=”” rule_size=”” animation_direction=”left” animation_color=”” animation_speed=”0.3″ animation_delay=”0″ logics=”” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky”]

Targeted knock-in of GFP + Puromycin (7kb) in HEK293 to compare the efficiency between Cas-CLOVER and CRISPR/Cas9

[/fusion_text][/fusion_builder_column][fusion_builder_column type=”2_3″ type=”2_3″ layout=”2_3″ align_self=”auto” content_layout=”column” align_content=”flex-start” valign_content=”flex-start” content_wrap=”wrap” spacing=”yes” center_content=”no” target=”_self” hide_on_mobile=”no” sticky_display=”normal,sticky” class=”max463-right spl-anchor ml55″ order_medium=”0″ order_small=”0″ margin_bottom=”20px” hover_type=”none” border_sizes_top=”0px” border_sizes_right=”0px” border_sizes_bottom=”0px” border_sizes_left=”0px” border_style=”solid” box_shadow=”no” box_shadow_blur=”0″ box_shadow_spread=”0″ background_type=”single” gradient_start_position=”0″ gradient_end_position=”100″ gradient_type=”linear” radial_direction=”center center” linear_angle=”180″ background_position=”left top” background_repeat=”no-repeat” background_blend_mode=”overlay” filter_type=”regular” filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″ animation_direction=”down” animation_speed=”0.1″ last=”false” border_position=”all” first=”true” spacing_left=”2%” min_height=”” link=””][fusion_text rule_style=”default” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” fusion_font_family_text_font=”Roboto” fusion_font_variant_text_font=”300″ line_height=”30px” text_transform=”none” animation_direction=”left” animation_speed=”0.3″]

Hera employs Cas-CLOVER, a dimeric gene editing system and CRISPR/Cas9 alternative with superior freedom to operate (FTO), to engineer cell lines with high-value modifications. This platform was used to create our proprietary CleanCut GS CHO cell line, and we now apply it to help clients enhance their host cells.

Cas-CLOVER delivers improved knock-in efficiency compared to CRISPR/Cas9, enabling precise insertion of genes of interest—including at safe harbor loci—while maintaining desirable cellular characteristics. When combined with Harbor-IN transposase, it further enables tunable copy number for optimized protein expression.

Ready To Advance Your Research?

[/fusion_title][fusion_text rule_style=”default” content_alignment=”center” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” class=”secSubTitle” font_size=”30″ text_transform=”none” animation_direction=”left” animation_speed=”0.3″ text_color=”#ffffff” fusion_font_variant_text_font=”400″ fusion_font_family_text_font=”Roboto”]

Let’s Talk

[/fusion_text][fusion_button link=”/contact-us/” target=”_self” alignment=”center” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” class=”homeHero__btn” color=”custom” button_gradient_top_color=”#ffffff” button_gradient_bottom_color=”#ffffff” button_gradient_top_color_hover=”rgba(255,255,255,0.95)” button_gradient_bottom_color_hover=”rgba(255,255,255,0.95)” linear_angle=”180″ accent_color=”#00467b” accent_hover_color=”#00467b” stretch=”default” margin_top=”10″ icon_position=”left” icon_divider=”no” animation_direction=”left” animation_speed=”0.3″ border_color=”#00467b” border_hover_color=”#00467b” size=”xlarge”]Schedule a Call [/fusion_button][/fusion_builder_column][/fusion_builder_row][/fusion_builder_container]