[fusion_builder_container hundred_percent=”no” hundred_percent_height=”no” hundred_percent_height_scroll=”no” align_content=”stretch” flex_align_items=”flex-start” flex_justify_content=”flex-start” hundred_percent_height_center_content=”yes” equal_height_columns=”no” container_tag=”div” hide_on_mobile=”no” status=”published” class=”bannersec” id=”bnr” padding_top=”130″ padding_bottom=”123″ border_sizes_top=”0px” border_sizes_right=”0px” border_sizes_bottom=”0px” border_sizes_left=”0px” border_color=”var(–awb-color1)” border_style=”solid” box_shadow=”no” box_shadow_blur=”0″ box_shadow_spread=”0″ gradient_start_position=”0″ gradient_end_position=”100″ gradient_type=”linear” radial_direction=”center center” linear_angle=”180″ background_color=”var(–awb-color1)” background_image=”http://herabiolabs.com/wp-content/uploads/2021/01/scientist-with-rat-1.jpg” background_position=”left bottom” background_repeat=”no-repeat” fade=”no” background_parallax=”none” enable_mobile=”no” parallax_speed=”0.3″ background_blend_mode=”none” video_aspect_ratio=”16:9″ video_loop=”yes” video_mute=”yes” absolute=”off” absolute_devices=”small,medium,large” sticky=”off” sticky_devices=”small-visibility,medium-visibility,large-visibility” sticky_transition_offset=”0″ scroll_offset=”0″ animation_direction=”left” animation_speed=”0.3″ filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″ flex_column_spacing=”0px” type=”flex”][fusion_builder_row][fusion_builder_column type=”1_1″ type=”1_1″ layout=”1_1″ last=”true” spacing=”yes” center_content=”no” hide_on_mobile=”no” background_repeat=”no-repeat” background_position=”left top” border_position=”all” border_style=”solid” animation_type=”0″ animation_direction=”down” animation_speed=”0.1″ class=”max463-right1″ border_sizes_top=”0px” border_sizes_bottom=”0px” border_sizes_left=”0px” border_sizes_right=”0px” first=”true” hover_type=”none” background_blend_mode=”overlay” min_height=”” link=””][fusion_title title_type=”text” loop_animation=”once” marquee_direction=”left” marquee_speed=”15000″ rotation_effect=”bounceIn” display_time=”1200″ highlight_effect=”circle” highlight_width=”9″ highlight_top_margin=”0″ title_link=”off” link_target=”_self” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” class=”hed1″ content_align=”left” size=”2″ text_shadow=”no” text_shadow_blur=”0″ text_stroke=”no” text_stroke_size=”1″ text_overflow=”none” gradient_font=”no” gradient_start_position=”0″ gradient_end_position=”100″ gradient_type=”linear” radial_direction=”center center” linear_angle=”180″ style_type=”none” animation_direction=”left” animation_speed=”0.3″ animation_delay=”0″]

The SRG Rat^®

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Sprague Dawley-Rag2^em2heraIl2rg^em1hera/HblCrl

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A Highly Immunodeficient Rat Strain for Xenograft Studies

[/fusion_text][/fusion_builder_column][/fusion_builder_row][/fusion_builder_container][fusion_builder_container hundred_percent=”no” hundred_percent_height=”no” hundred_percent_height_scroll=”no” align_content=”stretch” flex_align_items=”flex-start” flex_justify_content=”flex-start” hundred_percent_height_center_content=”yes” equal_height_columns=”no” container_tag=”div” hide_on_mobile=”no” status=”published” class=”sec1″ id=”cro” padding_top=”79px” padding_bottom=”34px” border_sizes_top=”0px” border_sizes_right=”0px” border_sizes_bottom=”0px” border_sizes_left=”0px” border_style=”solid” box_shadow=”no” box_shadow_blur=”0″ box_shadow_spread=”0″ gradient_start_position=”0″ gradient_end_position=”100″ gradient_type=”linear” radial_direction=”center center” linear_angle=”180″ background_color=”var(–awb-color4)” background_position=”left top” background_repeat=”no-repeat” fade=”no” background_parallax=”none” enable_mobile=”no” parallax_speed=”0.3″ background_blend_mode=”none” video_aspect_ratio=”16:9″ video_loop=”yes” video_mute=”yes” absolute=”off” absolute_devices=”small,medium,large” sticky=”off” sticky_devices=”small-visibility,medium-visibility,large-visibility” sticky_transition_offset=”0″ scroll_offset=”0″ animation_direction=”left” animation_speed=”0.3″ filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″ flex_column_spacing=”0px” type=”flex”][fusion_builder_row][fusion_builder_column type=”1_1″ type=”1_1″ layout=”1_1″ align_self=”auto” content_layout=”column” align_content=”flex-start” valign_content=”flex-start” content_wrap=”wrap” spacing=”yes” center_content=”no” target=”_self” hide_on_mobile=”no” sticky_display=”normal,sticky” order_medium=”0″ order_small=”0″ hover_type=”none” border_sizes_top=”0px” border_sizes_right=”0px” border_sizes_bottom=”0px” border_sizes_left=”0px” border_style=”solid” box_shadow=”no” box_shadow_blur=”0″ box_shadow_spread=”0″ background_type=”single” gradient_start_position=”0″ gradient_end_position=”100″ gradient_type=”linear” radial_direction=”center center” linear_angle=”180″ background_color=”var(–awb-color4)” background_position=”left top” background_repeat=”no-repeat” background_blend_mode=”none” filter_type=”regular” filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″ animation_direction=”left” animation_speed=”0.1″ last=”true” border_position=”all” first=”true” min_height=”” link=””][fusion_text]

The SRG rat is a SCID model created through knockout mutations in the Rag2 and Il2rgamma genes, resulting in a loss of mature B, T, and NK cells. This immunodeficient phenotype makes the SRG rat ideal for the engraftment of human tissue.

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Leveraging the Sprague Dawley background and the larger organism size, SRG users have found these rats uniquely optimal for combining efficacy, pharmacokinetic (PK), biomarker, and toxicology-related endpoints.

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Access SRG rats or research services directly from our trusted partner, Charles River Laboratories, or conduct your own studies in-house or with a CRO of your choice. 

[/fusion_text][/fusion_builder_column][/fusion_builder_row][/fusion_builder_container][fusion_builder_container hundred_percent=”no” hundred_percent_height=”no” hundred_percent_height_scroll=”no” align_content=”stretch” flex_align_items=”stretch” flex_justify_content=”flex-start” hundred_percent_height_center_content=”yes” equal_height_columns=”yes” container_tag=”div” hide_on_mobile=”no” status=”published” class=”sec3 zigzag-section wuaSRGRModel” padding_top=”138px” padding_bottom=”100px” border_sizes_top=”0px” border_sizes_right=”0px” border_sizes_bottom=”0px” border_sizes_left=”0px” border_style=”solid” box_shadow=”no” box_shadow_blur=”0″ box_shadow_spread=”0″ gradient_start_position=”0″ gradient_end_position=”100″ gradient_type=”linear” radial_direction=”center center” linear_angle=”180″ background_position=”left top” background_repeat=”no-repeat” fade=”no” background_parallax=”none” enable_mobile=”no” parallax_speed=”0.3″ background_blend_mode=”none” video_aspect_ratio=”16:9″ video_loop=”yes” video_mute=”yes” absolute=”off” absolute_devices=”small,medium,large” sticky=”off” sticky_devices=”small-visibility,medium-visibility,large-visibility” sticky_transition_offset=”0″ scroll_offset=”0″ animation_direction=”left” animation_speed=”0.3″ filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″ type=”flex”][fusion_builder_row][fusion_builder_column type=”1_2″ type=”1_2″ layout=”1_2″ last=”false” spacing=”yes” center_content=”no” hide_on_mobile=”no” background_repeat=”no-repeat” background_position=”left top” border_position=”all” border_style=”solid” margin_bottom=”20px” animation_type=”0″ animation_direction=”down” animation_speed=”0.1″ class=”max463-left” border_sizes_top=”0px” border_sizes_bottom=”0px” border_sizes_left=”0px” border_sizes_right=”0px” first=”true” spacing_right=”2%” hover_type=”none” background_blend_mode=”overlay” min_height=”” link=””][fusion_title size=”2″ content_align=”left” style_type=”none” class=”hed1 hedm”]

What’s Unique About The SRG Rat Model?

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While some immunodeficient rodent strains, such as the Nude rat, are partially immunodeficient (missing T-cells), this enhanced immunodeficient rat model has a severely impaired immune system lacking B-cells, T-cells, and NK-cells.

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The SRG Rat model demonstrates enhanced utility, such as high tumor take rates and favorable growth kinetics for both cancer cell-line xenografts and PDX models. The model overcomes the limitations of smaller mouse models, enabling larger tumor growth, easier surgeries, and more tissues and serum for analyses, including repeat sampling.

[/fusion_text][fusion_button link=”/wp-content/uploads/2025/07/SRG-Rat-Validated-Models.pdf” title=”Download” target=”_blank” alignment=”left” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” color=”custom” button_gradient_top_color=”#19a64a” button_gradient_bottom_color=”#19a64a” button_gradient_top_color_hover=”#19a64a” button_gradient_bottom_color_hover=”#19a64a” accent_color=”#ffffff” accent_hover_color=”#ffffff” type=”flat” border_color=”#ffffff” border_hover_color=”#ffffff” size=”xlarge” stretch=”no” icon_position=”left” icon_divider=”no” animation_direction=”left” animation_speed=”1″ dynamic_params=”e30=”]Download Datasheet[/fusion_button][/fusion_builder_column][fusion_builder_column type=”1_2″ type=”1_2″ layout=”1_2″ last=”true” spacing=”yes” center_content=”no” hide_on_mobile=”no” background_repeat=”no-repeat” background_position=”left top” border_position=”all” border_style=”solid” margin_bottom=”20px” animation_type=”0″ animation_direction=”down” animation_speed=”0.1″ border_sizes_top=”0px” border_sizes_bottom=”0px” border_sizes_left=”0px” border_sizes_right=”0px” first=”false” spacing_left=”2%” hover_type=”none” background_blend_mode=”overlay” min_height=”” link=””][fusion_imageframe lightbox=”no” style_type=”none” hover_type=”none” bordersize=”0px” borderradius=”0″ align=”center” linktarget=”_self” animation_type=”0″ animation_direction=”down” animation_speed=”0.1″ hide_on_mobile=”no” class=”fullimg”] [/fusion_imageframe][/fusion_builder_column][/fusion_builder_row][/fusion_builder_container][fusion_builder_container hundred_percent=”no” hundred_percent_height=”no” hundred_percent_height_scroll=”no” align_content=”stretch” flex_align_items=”flex-start” flex_justify_content=”flex-start” hundred_percent_height_center_content=”yes” equal_height_columns=”no” container_tag=”div” hide_on_mobile=”no” status=”published” class=”sec1″ id=”cro” padding_top=”65px” padding_bottom=”46px” border_sizes_top=”0px” border_sizes_right=”0px” border_sizes_bottom=”0px” border_sizes_left=”0px” border_style=”solid” box_shadow=”no” box_shadow_blur=”0″ box_shadow_spread=”0″ gradient_start_position=”0″ gradient_end_position=”100″ gradient_type=”linear” radial_direction=”center center” linear_angle=”180″ background_color=”#d2d1d6″ background_position=”left top” background_repeat=”no-repeat” fade=”no” background_parallax=”none” enable_mobile=”no” parallax_speed=”0.3″ background_blend_mode=”none” video_aspect_ratio=”16:9″ video_loop=”yes” video_mute=”yes” absolute=”off” absolute_devices=”small,medium,large” sticky=”off” sticky_devices=”small-visibility,medium-visibility,large-visibility” sticky_transition_offset=”0″ scroll_offset=”0″ animation_direction=”left” animation_speed=”0.3″ filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″ admin_toggled=”yes” type=”flex”][fusion_builder_row][fusion_builder_column type=”3_4″ type=”3_4″ layout=”1_1″ last=”false” spacing=”yes” center_content=”no” hide_on_mobile=”no” background_repeat=”no-repeat” background_position=”left top” border_position=”all” animation_speed=”0.1″ border_sizes_top=”0px” border_sizes_bottom=”0px” border_sizes_left=”0px” border_sizes_right=”0px” first=”true” hover_type=”none” spacing_right=”3%” background_blend_mode=”overlay” min_height=”” link=””][fusion_text rule_style=”default” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” text_transform=”none” animation_direction=”left” animation_speed=”0.3″]

Exclusive SRG distribution partnership
with Charles River

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Charles River Laboratories (CRL) is Hera’s exclusive global distributor for the SRG rat. All orders are processed and fulfilled by CRL, which also offers preclinical services using the SRG platform. Learn more about SRG rat from Charles River.

[/fusion_text][fusion_button link=”https://www.criver.com/products-services/find-model/srg-rat?region=3611″ title=”Press Release” target=”_blank” alignment=”center” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” color=”custom” button_gradient_top_color=”#19a64a” button_gradient_bottom_color=”#19a64a” button_gradient_top_color_hover=”#19a64a” button_gradient_bottom_color_hover=”#19a64a” accent_color=”#ffffff” accent_hover_color=”#ffffff” type=”flat” border_color=”#ffffff” border_hover_color=”#ffffff” size=”xlarge” stretch=”no” icon_position=”left” icon_divider=”no” animation_direction=”left” animation_speed=”1″]Order the SRG[/fusion_button][/fusion_builder_column][/fusion_builder_row][/fusion_builder_container][fusion_builder_container background_parallax=”none” enable_mobile=”no” parallax_speed=”0.3″ background_repeat=”no-repeat” background_position=”left top” video_aspect_ratio=”16:9″ video_mute=”yes” video_loop=”yes” fade=”no” border_style=”solid” padding_top=”78px” padding_bottom=”45px” hundred_percent=”no” equal_height_columns=”yes” hide_on_mobile=”no” class=”sec3 zigzag-section zigzag-section-reverse” flex_align_items=”stretch” border_sizes_top=”0px” border_sizes_bottom=”0px” border_sizes_left=”0px” border_sizes_right=”0px” type=”flex”][fusion_builder_row][fusion_builder_column type=”1_2″ type=”1_2″ layout=”1_2″ last=”false” spacing=”yes” center_content=”no” hide_on_mobile=”no” background_repeat=”no-repeat” background_position=”left top” border_position=”all” border_style=”solid” margin_bottom=”20px” animation_type=”0″ animation_direction=”down” animation_speed=”0.1″ border_sizes_top=”0px” border_sizes_bottom=”0px” border_sizes_left=”0px” border_sizes_right=”0px” first=”true” spacing_right=”2%” hover_type=”none” background_blend_mode=”overlay” min_height=”” link=””][fusion_imageframe lightbox=”no” style_type=”none” hover_type=”none” bordersize=”0px” borderradius=”0″ align=”center” linktarget=”_self” animation_type=”0″ animation_direction=”down” animation_speed=”0.1″ hide_on_mobile=”no” class=”fullimg”] [/fusion_imageframe][/fusion_builder_column][fusion_builder_column type=”1_2″ type=”1_2″ layout=”1_2″ last=”true” spacing=”yes” center_content=”no” hide_on_mobile=”no” background_repeat=”no-repeat” background_position=”left top” border_position=”all” border_style=”solid” margin_bottom=”20px” animation_type=”0″ animation_direction=”down” animation_speed=”0.1″ class=”max463-right” border_sizes_top=”0px” border_sizes_bottom=”0px” border_sizes_left=”0px” border_sizes_right=”0px” first=”false” spacing_left=”2%” hover_type=”none” background_blend_mode=”overlay” min_height=”” link=””][fusion_title size=”2″ content_align=”left” style_type=”none” class=”hed1 hedm”]

Validated Using Difficult Xenograft and Patient Derived Xenograft (PDX) Models

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The SRG rat supports a tumor microenvironment that more closely mimics human biology than mouse models. Data indicate that SRG rats better preserve the architectural and stromal components of patient-derived tumors, enhancing the translational relevance of xenograft and PDX studies. This feature is particularly valuable for evaluating immunomodulatory therapies, where a supportive microenvironment is critical. View supporting data (PDF).

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The SRG Rat has been validated using a wide range of xenografts that consistently demonstrate high tumor take rates with traditionally difficult-to-engraft cell lines, such as VCaP prostate cancer, H358 non-small cell lung cancer (NSCLC), and prostate, NSCLC, and ovarian PDX models.

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Additionally, humane endpoints allow for subcutaneously implanted xenograft and PDX models to reach 10X tumor volumes, up to >20,000 mm³, compared to mouse xenografts, allowing for serial tumor sampling or faster PDX establishment.

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How Is The SRG Rat Better Than SCID Mice?

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The SRG rat enables improved imaging capabilities over mouse models, including PET/CT and bioluminescence, due to its larger size and stable tumor growth. Studies have shown that tumors in SRG rats are more readily detected at earlier timepoints and support serial imaging workflows for preclinical therapeutic evaluation. View imaging study (PDF).

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Through the use of the SRG Rat, researchers can collect more consistent, higher-quality data that provides advantages for predicting success in the clinic.

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Xenografts in the larger SRG Rat models can display vastly improved engraftment efficiencies, tumor size, growth, and tumor morphology across a number of human cancer cell lines and patient-derived tissues that are either not permissive or extremely inefficient in mice.

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Cancer Researchers Find Success With SRG Rat Models

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A team of researchers led by Dr. Ramesh Narayanan at the University of Tennessee partnered with Hera BioLabs to evaluate new therapeutics for castration-resistant prostate cancer (CRPC), targeting androgen receptors (ARs).

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Given the need for prostate cancer xenografts which model high AR-expression amplification phenotype found in many CRPC patients, the SRG rat has high tumor take rates of prostate cancer xenograft cell lines such as LNCaP & VCaP (>90%) which are prohibitively inefficient in mouse. Hera has expanded our capabilities to include validated castration-resistant and enzalutamide-resistant models.

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“The tumor uptake rate was to 80-100%, which is a huge advantage because what we could achieve as a statistical significance with 8-12 mice, can be achieved with 5-6 OncoRats.”

[/fusion_text][fusion_title size=”2″ content_align=”left” style_type=”none” class=”hed1 hedm”]

Ramesh Narayanan, Ph.D.

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Associate Professor of Medicine & Hematology
University of Tennessee Health Science Center

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Creating the SRG Rat

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The SRG Platform is a Sprague-Dawley rat with a double knockout for the Rag2 and Il2rgamma genes (SD-Rag2tm2hera Il2rgtm1hera). SRG is a severely immunodeficient rat that lacks B-cells, T-cells, and NK-cells and was first introduced to enable and accelerate xenograft efficacy studies.

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Background

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Cutting-edge gene-editing technologies Cas-CLOVER and super piggyBac® enabled Hera to precisely engineer animal models and cell systems. Due to limitations of mouse models for oncology and the improved translatability of rats, Hera set out to create the ultimate rat model for oncology. The SRG Rat Platform was created through targeted-nuclease mediated gene disruption of the rat Rag2 and Il2rg genes. It contains an 8 bp deletion in the Rag2 gene causing defective V(D)J recombination, preventing T cell and B cell development. SRG also has a 16 bp deletion in the Il2rg gene, which leads to a lack of cytokine signaling, resulting in defective lymphoid development. The combined mutations result in a SCID rat with loss of mature B, T, and NK cells.

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Phenotype & Applications

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The SRG has a SCID rat phenotype and accepts human tissue as a xenograft model. The SRG Rat has been validated with a wide range of xenograft models, including patient-derived xenografts (PDX), and consistently demonstrates improved tumor take rates and delivers tumor sizes 10x that of mouse models in half the time. For translational research, the rat produces blood and tissue samples ten times larger than mice and is metabolically closer to humans. Since the rat is the preferred model for pharmacokinetics (PK) and toxicology, the SRG is ideally suited for efficacy and PK/toxicology studies in the same animal.

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Immunophenotype of the SRG Platform

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• A) CD4+/CD8+ mature T cells are absent.
• B) The spleen contains no mature B cells as demonstrated by lack of CD45R (B220)+/IgM+ cells.
• C) The Il2rg knockout results in a reduced NK cell population in the spleen.

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Comparison between Nude rats and the SRG rat show a severally reduced number of natural killer (NK) cells in the circulating blood.

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Additional Resources

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We have compiled answers to frequent questions about our novel SRG OncoRat®. If you still have questions, feel free to contact us.

What is the SRG Rat?

The Sprague Dawley-Rag2-Il2rg knockout rat strain is commonly referred to as the SRG Rat or the OncoRat. It has a Sprague Dawley background containing a double knockout of the Rag2 and Il2rg genes. The combined mutations result in a loss of mature B, T, and NK cells, making it the most severely immunodeficient rat model on the market.

What services does Hera provide?

Hera no longer provides in vivo contract research (CRO) services. However, the SRG rat is available for purchase through Charles River Laboratories (CRL), and studies using the SRG rat can be conducted at a number of top-tier CROs worldwide, including CRL.

What cancer types grow in the SRG rat?

The SRG rat is an ideal host for cancer xenografts (or PDXs) because it is highly immunodeficient. Almost all cancer types have been tested in the SRG rat, which generally demonstrates highly uniform tumor growth and nearly 100% tumor take rates.

Can the SRG rat be humanized?

The SRG is amenable to engraftment of human tissue(s), including those used for humanization of the immune system and humanization of the liver. Several approaches to SRG rat humanization—such as PBMC engraftment, hematopoietic stem cell transplantation, and the BLT method—have been demonstrated in the scientific literature. These models support the study of immunotherapies, GVHD, and infectious diseases, as well as applications in pharmacology and toxicology. View published study (Nature).

What are the applications of the SRG rat?

The SRG rat can be used in place of any immunodeficient mouse strain, while providing many advantages such as larger sample collection, a more translational metabolism, easier surgeries, etc. In addition to oncology and immuno-oncology applications, the SRG rat can also be used for medical device implantations, allografts/regenerative medicine, hearing or ocular assessments, as well as provide pharmacology and toxicology endpoints on the preferred Sprague Dawley background alongside efficacy data.

Can the SRG rat be used for continuous IV dosing?

SRG rats have undergone implantation of Vascular Access Buttons (VABs) and other surgeries. The larger size of the SRG rat makes it an ideal host for implanted pumps (Alzet or Iprecio).

How many cancer cells should I use for my xenograft/PDX?

The SRG rat is highly amenable to engrafting human xenografts and PDXs. For studies we conduct on behalf of our clients, we typically implant between 1 and 10 million cancer cells into the subcutaneous space. When implanting a PDX, Hera uses a 2 x 2 x 2 mm tissue.

Can I purchase SRG Rats for my research?

Hera has licensed the SRG rat to Charles River for distribution directly to the global preclinical research community. As of April 15, 2022, all orders will be placed with and fulfilled by Charles River. Orders can be placed on the Charles River website HERE.

Do the SRG rats require a special diet or housing conditions?

SRG rats should be housed in IVC cages or a barrier facility, if possible. Their immunodeficient phenotype leads to a susceptibility to opportunistic pathogens which should be taken into consideration, as is the case with any immunodeficient strain. Other than that, the SRG does not require any special diet or care and maintenance procedures. Standard irradiated rodent chow is used.

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 For a full list of resources on our SRG rat please visit our PUBLICATIONS page.

1. Noto, F. K., Adjan-Steffey, V., Tong, M., Ravichandran, K., Zhang, W., Arey, A., McClain, C. B., Ostertag, E., Mazhar, S., Sangodkar, J., DiFeo, A., Crawford, J., Narla, G., & Jamling, T. Y. (2018). Sprague Dawley Rag2-Null Rats Created from Engineered Spermatogonial Stem Cells Are Immunodeficient and Permissive to Human Xenografts. Molecular cancer therapeutics, 17(11), 2481–2489. https://doi.org/10.1158/1535-7163.MCT-18-0156
2. Ponnusamy, S., He, Y., Hwang, D. J., Thiyagarajan, T., Houtman, R., Bocharova, V., Sumpter, B. G., Fernandez, E., Johnson, D., Du, Z., Pfeffer, L. M., Getzenberg, R. H., McEwan, I. J., Miller, D. D., & Narayanan, R. (2019). Orally Bioavailable Androgen Receptor Degrader, Potential Next-Generation Therapeutic for Enzalutamide-Resistant Prostate Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research, 25(22), 6764–6780. https://doi.org/10.1158/1078-0432.CCR-19-1458 
3. Maulhardt, H. A., Hylle, L., Frost, M. V., Tornio, A., Dafoe, S., Drummond, L., Quinn, D. I., Kamat, A. M., & diZerega, G. S. (2019). Local Injection of Submicron Particle Docetaxel is Associated with Tumor Eradication, Reduced Systemic Toxicity and an Immunologic Response in Uro-Oncologic Xenografts. Cancers, 11(4), 577. https://doi.org/10.3390/cancers11040577

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