Shop Gene Editing
Reagents For
Drug Discovery

Hera’s gene editing technology is perfect for a wide range of applications, including in vivo gene expression or modifications, stable cell lines, and other complex gene editing strategies. Order gene editing reagents or inquire about Hera’s custom reagent design services.

Demonstrated in hundreds of peer-reviewed publications, the piggyBac transposon mediates efficient stable genomic transgene insertion. Use your preferred transfection method to deliver a piggyBac transposon containing your gene(s) of interest along with the piggyBac transposase as DNA or mRNA.

A limited-use research license is required to evaluate the piggyBac and Cas-CLOVER technology. For end-user license information, click here.

Shop Gene Editing Reagents

PIGGYBAC REAGENTS & SERVICES

piggyBac Starter Kit

OTS REAGENT(s) CATALOG # SHORT DESCRIPTION AMOUNT MAP LICENSE FEE
piggyBac REAGENTS, SERVICES & LICENSE SPB-E12
The piggyBac starter kit includes the SPB-012 transposon with GFP/Puro expression and

SPB-100 piggyBac mRNA.

10ug DNA

25 ug RNA

Map
Sequence
$899.00 Request a Quote

TRANSPOSONS

OTS REAGENT CATALOG # SHORT DESCRIPTION AMOUNT MAP LICENSE FEE
piggyBac REAGENTS, SERVICES & LICENSE SPB-007
Empty piggyBac transposon base vector with multiple cloning site (MSC)
10ug Map
Sequence
$980.00 Request a Quote
piggyBac REAGENTS, SERVICES & LICENSE SPB-012
piggyBac transposon containing a CMV promoter-MCS-SV40PolyA for cloning gene of interest and a GFP-Puro selection cassette.
10ug Map
Sequence
$980.00 Request a Quote
piggyBac REAGENTS, SERVICES & LICENSE SPB-013
piggyBac transposon containing a CAG promoter-MCS-SV40PolyA for cloning gene of interest and a GFP-Puro selection cassette.
10ug Map
Sequence
$980.00 Request a Quote
piggyBac REAGENTS, SERVICES & LICENSE SPB-014
piggyBac transposon containing a PGK promoter-MCS-SV40PolyA for cloning gene of interest and a GFP-Puro selection cassette.
10ug Map
Sequence
$980.00 Request a Quote
piggyBac REAGENTS, SERVICES & LICENSE SPB-015
piggyBac transposon containing an Ef1a promoter-MCS-SV40PolyA for cloning gene of interest and a GFP-Puro selection cassette.
10ug Map
Sequence
$980.00 Request a Quote

TRANSPOSASES

OTS REAGENT CATALOG # SHORT DESCRIPTION AMOUNT MAP LICENSE FEE
piggyBac REAGENTS, SERVICES & LICENSE SPB-110
Improved super piggyBac transposase (sPBo) mRNA
10ug $455.00 Request a Quote
piggyBac REAGENTS, SERVICES & LICENSE SPB-100
Improved super piggyBac transposase (sPBo) mRNA
25ug $990.00 Request a Quote
piggyBac REAGENTS, SERVICES & LICENSE SPB-D10
Improved super piggyBac transposase (sPBo) DNA
10ug View Map $535.00 Request a Quote
piggyBac REAGENTS, SERVICES & LICENSE SPB-D25
Improved super piggyBac transposase (sPBo) DNA
25ug View Map $1,330.00 Request a Quote
piggyBac REAGENTS, SERVICES & LICENSE SPB-002
Excision-only piggyBac transposase DNA
25ug View Map $1,330.00 Request a Quote
piggyBac REAGENTS, SERVICES & LICENSE SPB-200
Improved super piggyBac transposase (sPBo)  mRNA
Commercial Grade for applications that  require a CoA and TSE/BSE Statement  
25ug $1,400.00 Request a Quote

All reagents are provided at a 1 ug/ul concentration per vial. Shipping for RNA reagents will be on dry ice (US) or LN2 cryoport (International). Shipping for DNA reagents will be ambient temperature or on ice. 

Transposases are designed for direct use and cannot be propagated. Inquire for bulk ordering or quality reports or documentation.

*The transfer of reagents is subject to a limited use research license pursuant to the terms and conditions. If use of the reagents beyond these terms and conditions is desired, please contact Hera at services@herabiolabs.com for technology licensing opportunities.

CAS-CLOVER NUCLEASES THE CLEAN ALTERNATIVE TO CRISPR/CAS9

Our high-precision dimeric Cas-CLOVER gene editing system is supported by clear issued patents and combines high efficiency with undetectable off-target activity. Transfect the Cas-CLOVER mRNA with a pair of gRNAs for targeted nuclease cutting.

We offer commercial and research licenses as well as proof of concept services for this technology in drug discovery & early development.

OTS REAGENT CATALOG # SHORT DESCRIPTION AMOUNT License Fee
Cas-CLOVER CCL-100
Cas-CLOVER mRNA
25ug $950.00 Request a Quote
Cas-CLOVER CCL-200
Cas-CLOVER custom gRNA pair (including design service)
50 ug/each $750.00 Request a Quote

FOOTPRINT FREE GENE EDITING® KITS

Footprint-Free Gene Editing combines piggyBac and Cas-CLOVER to allow for selection of gene editing events without leaving scarring sequences behind allowing for complex edits in even the most difficult cell lines. Our custom gene editing kits includes everything you need for targeted knock-ins. Or select one of our Multivector backbones and design your own project.

OTS REAGENT CATALOG # SHORT DESCRIPTION AMOUNT MAP PRICE
FOOTPRINT-FREE GENE EDITING KITS SGK – 010
Custom Footprint-Free Gene Editing Kit (SGK-00X with custom HR arms, CCL-100, CCL-200, and SPB-002)
$5,500.00 Request a Quote
FOOTPRINT-FREE GENE EDITING KITS SGK – 001
Empty Multivector containing GFP and Puromycin selection cassette driven by a CMV promoter (MV-CMV-GFP-Puro).
View Map $1,399.00 Request a Quote
FOOTPRINT-FREE GENE EDITING KITS SGK – 002
Empty Multivector containing GFP and Puromycin selection cassette driven by a PGK promoter (MV-PGK-GFP-Puro).
View Map $1,399.00 Request a Quote
FOOTPRINT-FREE GENE EDITING KITS SGK – 004
Empty Multivector containing Neomycin and Thymidine Kinase selection cassette driven by a PGK promoter (MV-PGKNeo-TK).
View Map $1,399.00 Request a Quote
FOOTPRINT-FREE GENE EDITING KITS SGK – 005
Empty Multivector containing Puromycin and Thymidine Kinase selection cassette driven by a PGK promoter (MV-PGKPuro-TK).
View Map $1,399.00 Request a Quote
FOOTPRINT-FREE GENE EDITING KITS SGK – 006
Empty Multivector containing Hygromycin and Thymidine Kinase selection cassette driven by a PGK promoter (MV-PGKHygro-TK).
View Map $1,399.00 Request a Quote
FOOTPRINT-FREE GENE EDITING KITS SGK – 007
Empty Multivector containing Puromycin and Thymidine Kinase selection cassette driven by an EF1α promoter (MVEF1α-Puro-TK).
View Map $1,399.00 Request a Quote

SAFE HARBOR SITE REAGENTS & KITS

AAVS1 donor vector and AAVS1-specific Cas-CLOVER nucleases for safe-harbor knock-in human cell lines. Simply clone in your gene of interest (GOI) into the donor vector and transfect along with the Cas-CLOVER gRNAs and Cas-CLOVER mRNA.  Alternative nucleases are also suitable (Cas9, TAL-CLOVER, etc.) for use with the donor vector. 

OTS REAGENT CATALOG # SHORT DESCRIPTION AMOUNT MAP PRICE
SAFE HARBOR AAVS1 REAGENTS & KITS KSH-001
AAVS1 GFP-Puro vector with Cas-CLOVER
10ug   $1,450.00 Request a Quote
SAFE HARBOR AAVS1 REAGENTS & KITS KSH-003
AAVS1 Puro-TK-SH vector with Cas-CLOVER
10ug   $1,450.00 Request a Quote
SAFE HARBOR AAVS1 REAGENTS & KITS KSH-005
AAVS1 MCS SH vector with Cas-CLOVER
10ug   $1,450.00 Request a Quote

All reagents are provided at a 1 ug/ul concentration per vial. Shipping for RNA reagents will be on dry ice (US) or LN2 cryoport (International). Shipping for DNA reagents will be at ambient temperature or on ice. 

piggyBac Citations

Cas-Clover Citations

Cell Line Engineering Services

Our cell-line engineering team can provide any modification including knock-in, knockout, and stable transgenic cell lines.  We have years of experience handling the toughest projects with our piggyBac and Cas-CLOVER products and offer highly flexible, milestone-based services.

Animal Model Creation Services

We develop custom genetically modified mouse and rat strains using our piggyBac and Cas-CLOVER technology. Seamless transitioning through phenotyping, characterization, and CRO services by a highly trained in-vivo team significantly reduces the timeline to data.

Mammalian Codon Optimized Cas-CLOVER mRNA

SKU: D001

Improved mRNA stability and protein expression in mammalian systems. Order custom designed and produced gRNAs from us (see options below) or your favorite provider and transform with the mRNA for clean editing.

25µg vial

$650

Plant Cas-CLOVER Gene Editing Plasmid Vector Suite

SKU: D001

T-DNA based plant transformation vectors for gene knockout in plants using the Cas-CLOVER system. The system is codon optimized for plant expression. Expression promoters for Cas-CLOVER, gRNA’s, selection markers and other details are listed below along with links to the maps.

All vectors are 5µg vial

$99

Yeast Cas-CLOVER Gene Editing Vector Suite

We offer a series of yeast-based shuttle vectors for the expression of a Saccharomyces cerevisiae codon optimized version of Cas-CLOVER. In this platform we have designed the plasmids such that gRNA expression is polyscistronic. Expression is driven by ScDMPR1, a proprietary promoter (information will be provided following your purchase), and individual guides are liberated via an intervening tRNA. Plasmids are offered on low copy CEN/ARS origin of replication.

Cas-CLOVER gRNA Design & Production Services

Cas-CLOVER gRNA Design Services

SKU: D004-1

Synthesis of 1 gRNA using state-of-the-art methods to be used for gene editing with Cas-CLOVER

1 gRNA

$99

Custom gRNA Production Services

SKU: D005

Synthesis of 1 pair (two gRNAs) using state-of-the-art methods to be used for gene editing with Cas-CLOVER

1 pair gRNA

$299

Validated in CHO Cells, Yeast, Plants & Human T-Cells

Cas-CLOVER has been validated in CHO cell lines and yeast for bioprocessing, plants for crop trait engineering and human T-cells for immunotherapy research..

To learn more about the area you are interested in, download the relevant industry datasheet.

Drug Discovery & Development

Advancing cell-line engineering for pharmaceutical research

Drug Discovery & Development

Advancing cell-line engineering for pharmaceutical research

Drug Discovery & Development

Advancing cell-line engineering for pharmaceutical research

Drug Discovery & Development

Advancing cell-line engineering for pharmaceutical research

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