What’s Old Is New Again: Chemical Carcinogenesis Models Of Cancer
Early cancer research focused primarily on chemical carcinogenesis in rat [...]
New Mouse Model Enables In Vivo Assessment Of Immunotherapies For Treating CGD
Chronic granulomatous disease (CGD) is best described as an immune [...]
Patient Derived Xenografts Possess Significant Advantages In The Study Of Urological Tumors
The more researchers learn about various cancers, the complexity of [...]
In Vivo Liver Gene Delivery
The in vivo delivery of transgenes into the liver of rats provide a rapid method for the creation of liver specific disease models, as well as gene therapy efficacy and toxicity testing models, without the time and cost for embryo modification and transgenic animal creation. By combining the highly efficient liver-targeting properties of rAAV with the piggyBac transposon, the transgene of interest stably integrates into the genome and is reliably expressed1.
Bacterial Carriers Offer New Hope In The Treatment Of Glioblastoma
Unlike many cancers, which have seen a tremendous increase in [...]
Rat Models Provide Superior Insights Into Mutagenic/Carcinogenic Responses In Humans
Although in-vitro bacterial mutation assays and murine models have long [...]
Chimeric Humanized Mouse Models: Understanding Human And Mouse Cell Interactions
Humanized liver mouse models are increasingly being used in preclinical [...]
Transposon Mutagenesis Helps Identify Genes Mediating Drug Resistance In The Treatment Of CLL
First time treatment of Chronic Lymphocratic Leukemia (CLL) generally requires [...]
PDX Models of Lung Cancer Closely Mimic Characteristics Of Patient Primary Tumors
Despite ongoing research, lung cancers have remained among the most [...]
Rat Provides A More Robust & Convenient Animal Infection Model For Hepatitis E Virus
Hepatitis E virus (HEV) is estimated to cause more than 56 thousand deaths each year, and although most infections remain asymptomatic, HEV is still considered one of the most common causes of acute viral hepatitis and is an ongoing concern for immunosuppressed transplant patients.