The OncoRat®: Hosting Valuable Tumor Xenograft Models That Are Difficult Or Impossible To Study Using In Vitro Or Mouse Models
One of the most widely used methods of modeling human [...]
OncoRat® PDX Models Highlighted In Drug Discovery News (DDN) Special Report On Cancer: Aiming For Avatars
While advances in in-vitro platforms have allowed researchers to better visually monitor a variety of aspects of tumor biology, a significant limitation of 3D cultured models for patient therapeutic monitoring or “patient avatars” is the lack of important components, such as the influence of surrounding tissues and potential cell-to-cell interactions, when studying cancer progression, treatment responses and outcomes. Patient derived xenograft models or PDX models overcome these limitations and other research challenges and provide a platform that is believed to more closely mimic the patient tumor.
Understanding Transporter-Mediated Drug-Drug Interactions Using Humanized Liver Mice
Pharmaceutical researchers and regulators are increasingly aware of the influence [...]
Using Patient Derived Xenografts To Improve Therapeutic Cancer Treatments
An increased understanding of human tumors has created a solid [...]
Humanized Mouse Models Advance Immunotherapeutic Strategies In Treatment Of Type 1 Diabetes
A relatively common autoimmune disease, Type 1 Diabetes (T1D) is [...]
Humanized Mouse Models Advance Immunotherapeutic Strategies In Treatment Of Type 1 Diabetes
A relatively common autoimmune disease, Type 1 Diabetes (T1D) is [...]
Humanized Mice Allow For Better Understanding Of Interactions Between VACV & Immune System
Cancer is responsible for approximately 8 million deaths worldwide, with [...]
Humanized Mouse Model Allows For Study Of Immune Response To Decellularized ECM Biomaterials
Humanized rodent models have been used extensively for studying autoimmune [...]
Early Discovery In Rats And Humanized Rodents
Do you have a compound and want a quick and cost effective in vivo evaluation? We offer a range of preliminary in vivo capabilities as well as the ability to screen compounds in both traditional animal rodent models, such as Sprague-Dawley rats and genetically engineered models (custom services & in vivo liver gene delivery available) including “humanized” liver rodent models, which are immunodeficient animals in which the native liver has been ablated and then engrafted with human hepatocytes, which proliferate to restore the functioning liver.
HIS Mice Provide New Preclinical Model For Human Skin Immunity
Despite the convenience and appeal of oral therapies, the reality [...]