Humanized Mouse Model Allows For Study Of Immune Response To Decellularized ECM Biomaterials
Humanized rodent models have been used extensively for studying autoimmune [...]
Humanized rodent models have been used extensively for studying autoimmune [...]
Do you have a compound and want a quick and cost effective in vivo evaluation? We offer a range of preliminary in vivo capabilities as well as the ability to screen compounds in both traditional animal rodent models, such as Sprague-Dawley rats and genetically engineered models (custom services & in vivo liver gene delivery available) including “humanized” liver rodent models, which are immunodeficient animals in which the native liver has been ablated and then engrafted with human hepatocytes, which proliferate to restore the functioning liver.
Despite the convenience and appeal of oral therapies, the reality [...]
Early cancer research focused primarily on chemical carcinogenesis in rat [...]
Chronic granulomatous disease (CGD) is best described as an immune [...]
The more researchers learn about various cancers, the complexity of [...]
The in vivo delivery of transgenes into the liver of rats provide a rapid method for the creation of liver specific disease models, as well as gene therapy efficacy and toxicity testing models, without the time and cost for embryo modification and transgenic animal creation. By combining the highly efficient liver-targeting properties of rAAV with the piggyBac transposon, the transgene of interest stably integrates into the genome and is reliably expressed1.
Unlike many cancers, which have seen a tremendous increase in [...]
Although in-vitro bacterial mutation assays and murine models have long [...]
Humanized liver mouse models are increasingly being used in preclinical [...]