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Diabetes & Metabolic Disorders 

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Accelerate your therapeutic development by leveraging our in vivo expertise and our obesity, metabolism, and diabetes models.

We pride ourselves on our ability to rapidly accommodate even the most difficult projects and deliver precise, unbiased, and timely results.

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Chemically Induced Diabetes

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• Streptozotocin (STZ) induced type 1 diabetes. 
• High fat diet (HFD) and STZ-induced type 2 diabetes Range finding or maximum tolerated dose studies

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filter_blur_hover=”0″]http://herabiolabs.com/wp-content/uploads/2023/05/STZ-Diabetes-.png[/fusion_imageframe][/fusion_builder_column][/fusion_builder_row][/fusion_builder_container][fusion_builder_container type=”legacy” hundred_percent=”no” hundred_percent_height=”no” hundred_percent_height_scroll=”no” align_content=”stretch” flex_align_items=”stretch” flex_justify_content=”flex-start” hundred_percent_height_center_content=”yes” equal_height_columns=”yes” container_tag=”div” hide_on_mobile=”no” status=”published” class=”sec3 zigzag-section nsec3 nsec32″ padding_right=”15%” padding_bottom=”100px” padding_left=”15%” border_sizes_top=”0px” border_sizes_right=”0px” border_sizes_bottom=”0px” border_sizes_left=”0px” border_style=”solid” box_shadow=”no” box_shadow_blur=”0″ box_shadow_spread=”0″ gradient_start_position=”0″ gradient_end_position=”100″ gradient_type=”linear” radial_direction=”center center” linear_angle=”180″ background_color=”#ffffff” background_position=”left top” 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Genetic Animal Models

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Our flexible services include standard genetic models of type 2 diabetes, glucose intolerance, and hyperinsulinemia (i.e. ZDF) and custom novel genetically engineered models.

[/fusion_text][fusion_button link=”http://herabiolabs.com/animal-model-creation/” target=”_self” alignment=”left” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” color=”custom” button_gradient_top_color=”#19a64a” button_gradient_bottom_color=”#19a64a” button_gradient_top_color_hover=”#19a64a” button_gradient_bottom_color_hover=”#19a64a” accent_color=”#ffffff” accent_hover_color=”#ffffff” type=”flat” border_color=”#ffffff” border_hover_color=”#ffffff” size=”xlarge” stretch=”no” icon_position=”left” icon_divider=”no” animation_direction=”left” animation_speed=”1″]Gene Editing Services[/fusion_button][/fusion_builder_column][/fusion_builder_row][/fusion_builder_container][fusion_builder_container type=”legacy” hundred_percent=”no” hundred_percent_height=”no” hundred_percent_height_scroll=”no” align_content=”stretch” flex_align_items=”stretch” flex_justify_content=”flex-start” hundred_percent_height_center_content=”yes” equal_height_columns=”yes” container_tag=”div” hide_on_mobile=”no” status=”published” class=”sec3 zigzag-section zigzag-section-reverse nsec33″ id=”zigzag-section-middle” padding_top=”0″ padding_right=”15%” padding_bottom=”100px” padding_left=”15%” border_sizes_top=”0px” border_sizes_right=”0px” border_sizes_bottom=”0px” border_sizes_left=”0px” border_style=”solid” box_shadow=”no” box_shadow_blur=”0″ box_shadow_spread=”0″ gradient_start_position=”0″ gradient_end_position=”100″ gradient_type=”linear” radial_direction=”center center” linear_angle=”180″ background_color=”#ffffff” background_position=”left top” background_repeat=”no-repeat” fade=”no” background_parallax=”none” enable_mobile=”no” parallax_speed=”0.3″ background_blend_mode=”none” video_aspect_ratio=”16:9″ video_loop=”yes” video_mute=”yes” absolute=”off” absolute_devices=”small,medium,large” sticky=”off” sticky_devices=”small-visibility,medium-visibility,large-visibility” sticky_transition_offset=”0″ scroll_offset=”0″ animation_direction=”left” animation_speed=”0.3″ filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″][fusion_builder_row][fusion_builder_column type=”1_2″ layout=”1_2″ align_self=”auto” content_layout=”column” align_content=”flex-start” valign_content=”flex-start” content_wrap=”wrap” spacing=”yes” center_content=”no” target=”_self” hide_on_mobile=”no” sticky_display=”normal,sticky” class=”max463-right” order_medium=”0″ order_small=”0″ spacing_left=”2%” margin_bottom=”20px” hover_type=”none” border_sizes_top=”0px” border_sizes_right=”0px” border_sizes_bottom=”0px” border_sizes_left=”0px” border_style=”solid” box_shadow=”no” box_shadow_blur=”0″ box_shadow_spread=”0″ background_type=”single” gradient_start_position=”0″ gradient_end_position=”100″ gradient_type=”linear” radial_direction=”center center” linear_angle=”180″ background_position=”left top” background_repeat=”no-repeat” background_blend_mode=”overlay” filter_type=”regular” filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″ animation_direction=”down” animation_speed=”0.1″ last=”false” border_position=”all” first=”true” min_height=”” link=””][fusion_title title_type=”text” rotation_effect=”bounceIn” display_time=”1200″ highlight_effect=”circle” loop_animation=”off” highlight_width=”9″ highlight_top_margin=”0″ title_link=”off” link_target=”_self” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” class=”hed1 hedm” content_align=”left” size=”2″ text_shadow=”no” text_shadow_blur=”0″ gradient_font=”no” gradient_start_position=”0″ gradient_end_position=”100″ gradient_type=”linear” radial_direction=”center center” linear_angle=”180″ style_type=”none” animation_direction=”left” animation_speed=”0.3″]

Nutritional Animal Models

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Diet-induced obesity models (DIO) including diet-induced obesity in our immunodeficient SRG Rat as the ideal model for cell therapy efficacy and safety testing.

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Cell Based Therapies in the SRG Rat

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SRG OncoRat, developed using Hera Biolabs’ advanced gene editing technology, is a SCID rat on the Sprague-Dawley background that harbors a double knockout for the Rag2 and Il2rgamma genes. Similar to industry leading NSG mice, OncoRat demonstrates enhanced immunodeficiency, lacking B-cells, T-cells, and NK-cells.

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Because the SRG rat is highly immunodeficient it is ideal for testing cell therapies in combination with standard methods of inducing an obesity or diabetes phenotype.

[/fusion_text][fusion_button link=”http://herabiolabs.com/the-srg-platform/” target=”_self” alignment=”left” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” color=”custom” button_gradient_top_color=”#19a64a” button_gradient_bottom_color=”#19a64a” button_gradient_top_color_hover=”#19a64a” button_gradient_bottom_color_hover=”#19a64a” accent_color=”#ffffff” accent_hover_color=”#ffffff” type=”flat” border_color=”#ffffff” border_hover_color=”#ffffff” size=”xlarge” stretch=”no” icon_position=”left” icon_divider=”no” animation_direction=”left” animation_speed=”1″]SRG Rats[/fusion_button][fusion_separator style_type=”none” top_margin=”10px” alignment=”center” /][/fusion_builder_column][/fusion_builder_row][/fusion_builder_container][fusion_builder_container type=”legacy” hundred_percent=”no” hundred_percent_height=”no” hundred_percent_height_scroll=”no” align_content=”stretch” flex_align_items=”stretch” flex_justify_content=”flex-start” hundred_percent_height_center_content=”yes” equal_height_columns=”yes” container_tag=”div” hide_on_mobile=”no” status=”published” class=”sec33″ id=”aaalac” padding_top=”58px” padding_right=”15%” padding_bottom=”40px” padding_left=”15%” border_sizes_top=”0px” border_sizes_right=”0px” border_sizes_bottom=”0px” border_sizes_left=”0px” border_style=”solid” box_shadow=”no” box_shadow_blur=”0″ box_shadow_spread=”0″ gradient_start_position=”0″ gradient_end_position=”100″ gradient_type=”linear” radial_direction=”center center” linear_angle=”180″ background_color=”#eaf3f9″ background_position=”left top” background_repeat=”no-repeat” fade=”no” background_parallax=”none” enable_mobile=”no” parallax_speed=”0.3″ background_blend_mode=”none” video_aspect_ratio=”16:9″ video_loop=”yes” video_mute=”yes” absolute=”off” absolute_devices=”small,medium,large” sticky=”off” sticky_devices=”small-visibility,medium-visibility,large-visibility” sticky_transition_offset=”0″ scroll_offset=”0″ animation_direction=”left” animation_speed=”0.3″ filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″][fusion_builder_row][fusion_builder_column type=”1_1″ layout=”1_1″ last=”true” spacing=”yes” center_content=”no” hide_on_mobile=”no” background_repeat=”no-repeat” background_position=”left top” border_position=”all” border_style=”solid” margin_bottom=”20px” animation_type=”0″ animation_direction=”down” animation_speed=”0.1″ border_sizes_top=”0px” border_sizes_bottom=”0px” border_sizes_left=”0px” border_sizes_right=”0px” first=”true” hover_type=”none” background_blend_mode=”overlay” min_height=”” link=””][fusion_title title_type=”text” rotation_effect=”bounceIn” display_time=”1200″ highlight_effect=”circle” loop_animation=”off” highlight_width=”9″ highlight_top_margin=”0″ title_link=”off” link_target=”_self” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” class=”hed1 hedm” content_align=”left” size=”2″ text_shadow=”no” text_shadow_blur=”0″ gradient_font=”no” gradient_start_position=”0″ gradient_end_position=”100″ gradient_type=”linear” radial_direction=”center center” linear_angle=”180″ style_type=”none” animation_direction=”left” animation_speed=”0.3″]

Available Assessments & Assays

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Glucose Homeostasis 

Insulin tolerance test (ITT; IP or IV)

Glucose tolerance test (GTT; PO, IP, or IV)

Glucose-stimulated insulin secretion (GSIS; PO, IP, or IV)

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Food intake, water intake, fecal output, fecal bomb calorimetry

Body composition (carcass):

Whole-body chemical carcass analysis

Dual-energy X-ray absorptiometry (DXA)

Quantitative magnetic resonance (QMR)

Dyslipidemia:

Total cholesterol, HDL, & LDL

Triglycerides

Free fatty acids

ELISA, Luminex®, and Meso Scale Discovery for Hormone Quantification

RNA, Protein, and Lipid Isolation

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Accelerate Your Pre-Clinical Cancer Research and Drug Development

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Contact us to learn more about our CRO services for oncology research.

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Choosing the Right Preclinical Rodent Model for Obesity Research

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Diabetes is a complex metabolic syndrome that affects millions of people worldwide. In preclinical research, selecting the appropriate animal model is crucial to studying the pathophysiology of diabetes and developing effective therapeutic interventions. Three commonly employed models include STZ-induced diabetes, diet-induced models, and genetically modified strains. Each model offers unique advantages and limitations, and understanding when to use them is essential for obtaining meaningful results.

STZ-Induced Diabetes Model: The streptozotocin (STZ)-induced diabetes model involves the administration of STZ, a naturally occurring compound that selectively destroys pancreatic beta cells, leading to insulin deficiency. This model mimics type 1 diabetes characterized by absolute insulin deficiency. STZ-induced diabetes is often used when studying autoimmune mechanisms, pancreatic beta cell transplantation, or evaluating novel therapeutic approaches aiming to restore insulin production. Researchers can control the severity of diabetes by adjusting the STZ dose, allowing for different degrees of beta cell destruction.

Diet-Induced Models: Diet-induced models involve feeding animals a high-fat or high-sugar diet, leading to obesity, insulin resistance, and eventual beta cell dysfunction. These models closely resemble type 2 diabetes, which is characterized by insulin resistance and relative insulin deficiency. Diet-induced models are versatile and widely used, as they reflect the lifestyle and dietary factors contributing to the development of type 2 diabetes in humans. They are particularly useful for studying metabolic abnormalities, glucose homeostasis, and exploring the effects of dietary interventions or pharmacological treatments.

Genetically Modified Strains: Genetically modified strains involve altering the genetic makeup of animals to mimic specific aspects of diabetes, such as impaired insulin signaling, defective beta cell function, or disrupted glucose metabolism. These models enable researchers to investigate the precise molecular mechanisms underlying diabetes. Genetically modified strains are valuable for understanding the genetic basis of diabetes and evaluating potential therapeutic targets. However, it is important to note that these models may not fully capture the complexity of the human disease and should be complemented with other models for comprehensive insights.

The choice of model depends on the specific research question and the aspect of diabetes being investigated and considering the research objectives, disease phenotype, and translational relevance, researchers can select the most appropriate model or you can let our scientific team provide expertise on the best model for your research goals.

Additional considerations:

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Insulin resistance lies at the heart of obesity-related metabolic dysfunction and to accurately study and dissect the underlying mechanisms, researchers rely on preclinical rodent models that faithfully replicate insulin resistance. Among the commonly used models, diet-induced obesity (DIO) mice stand out. By subjecting these mice to a high-fat or high-sugar diet, researchers can induce rapid and excessive weight gain, closely mirroring the development of obesity and associated insulin resistance in humans.

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Elevated blood glucose levels are a key characteristic of obesity and insulin resistance and effective preclinical rodent models should exhibit dysregulated blood glucose levels to mirror the metabolic abnormalities observed in obese individuals.  Diet-induced obesity (DIO)  models demonstrate higher fasting glucose levels and impaired glucose tolerance, providing researchers with a model system to study the intricate regulation of blood glucose and its impact on obesity-related metabolic complications.

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The role of diet in obesity research cannot be overstated. Preclinical rodent models offer the opportunity to study the effects of different dietary compositions on weight gain, metabolic dysfunction, and associated pathologies. DIO mice, when exposed to a high-fat or high-sugar diet, provide researchers with a valuable model to investigate the complex interplay between dietary factors, weight gain, adipose tissue expansion, and the development of insulin resistance.

[/fusion_toggle][fusion_toggle title=”Adipose Tissue Biology” open=”no”]

Adipose tissue, the primary site of energy storage, undergoes significant changes in obesity. It serves as an active endocrine organ, releasing adipokines and influencing systemic metabolism. Both DIO mice and other relevant models develop excess adipose tissue, especially in visceral depots, enabling researchers to study adipose tissue biology, including adipocyte hypertrophy, inflammation, and the impact of adipose tissue dysfunction on insulin sensitivity.

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Obesity-related metabolic disorders exert detrimental effects on the liver, leading to hepatic steatosis and non-alcoholic fatty liver disease (NAFLD). Preclinical rodent models, including C57BL/6J mice, develop hepatic steatosis due to obesity and insulin resistance, enabling researchers to study the underlying mechanisms, such as altered lipid metabolism, hepatic inflammation, and fibrosis. These models contribute to our understanding of hepatic pathophysiology and facilitate the development of therapeutic interventions for NAFLD.

[/fusion_toggle][fusion_toggle title=” Hyperglycemia and Insulin Sensitivity” open=”no”]

Hyperglycemia, a consequence of insulin resistance, is a hallmark of obesity-related metabolic dysfunction. By selecting appropriate rodent models, researchers can investigate hyperglycemia and impaired insulin sensitivity. DIO mice, exhibiting hyperglycemia and reduced insulin sensitivity, enable researchers to explore the interplay between glucose regulation, insulin action, and the development of metabolic complications. These models serve as a testing ground for interventions aiming to improve insulin sensitivity and normalize blood glucose levels.

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Ready To Advance Your Research?

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Let’s Talk

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